Anti-PLA2R antibodies

Diagnosis, prognosis and therapy control of primary membranous nephropathy

Primary membranous nephropathy (pMN) is an autoimmune disease characterised by the accumulation of immune complexes in the renal glomeruli. It is the most common cause of nephrotic syndrome in adults.

Antibodies to the phospholipase A2 receptor (PLA2R) occur in 70% to 80% of patients. Less frequently (in up to 10%), antibodies against thrombospondin type-1 domain-containing 7A (THSD7A) are determined. The detection of antibodies in serum is crucial for the diagnosis of pMN and may make a kidney biopsy unnecessary. In addition, disease activity and therapy response can be monitored by the measurement of the autoantibodies.

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Do you suffer from membranous nephropathy? Learn more about the disease, its diagnosis and therapy monitoring.

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Physicians & Laboratories

Are you a physician or laboratory technician? Here you will find detailed information on the disease, laboratory diagnostics and therapy monitoring.

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Are you interested in further specialised information? Exciting scientific lectures and webinars on membranous nephropathy can be found here.